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Non-nitrogen containing compounds

Etidronate (Didronel)

Clodronate

Tiludronate


Nitrogen-containing compounds

Pamidronate  (Aredia)

Alendronate  (Fosamax)

Risedronate  (Actonel)

Zoledronate  (Zometa)

Ibandronate  (Boniva)


Mechanism of action: Antiresorptive

Complications: Serious esophageal events

Prescription:  

Must be taken on an empty stomach

Overnight fast

With 8 oz of water by mouth

For at least 30 minutes remain upright (seated or standing)


Bisphosphonates and Reports of Bone, Joint and/or Muscle Pain. U.S. Food and Drug Administration. FDA Alert: Information for Healthcare Professionals: Bisphosphonates (marketed as Actonel, Actonel+Ca, Aredia, Boniva, Didronel, Fosamax, Fosamax+D, Reclast, Skelid, and Zometa). January 7, 2008


Osteonecrosis of the Jaw (ONJ)


Bisphosphonates