Tel: (410) 581 2969                 Fax: (410) 581 5775

20 Crossroads Dr, Suite 210  Owings Mills, MD 21117

Non-nitrogen containing compounds

Etidronate (Didronel)



Nitrogen-containing compounds

Pamidronate  (Aredia)

Alendronate  (Fosamax)

Risedronate  (Actonel)

Zoledronate  (Zometa)

Ibandronate  (Boniva)

Mechanism of action: Antiresorptive

Complications: Serious esophageal events


Must be taken on an empty stomach

Overnight fast

With 8 oz of water by mouth

For at least 30 minutes remain upright (seated or standing)

Bisphosphonates and Reports of Bone, Joint and/or Muscle Pain. U.S. Food and Drug Administration. FDA Alert: Information for Healthcare Professionals: Bisphosphonates (marketed as Actonel, Actonel+Ca, Aredia, Boniva, Didronel, Fosamax, Fosamax+D, Reclast, Skelid, and Zometa). January 7, 2008

Osteonecrosis of the Jaw (ONJ)